If you suspect your PC is infected with malware and all other Antivirus scans (including the Boot-time scan) were unable to resolve the issue. Creating and using Rescue Disk in Avast Antivirus. Below you can see the example of how the boot-time scan looks in the Avast antivirus 2016.
If your computer has a rootkit, the malware may be able to hide itself from your antivirus software. If your computer is infected with malware, running an antivirus within Windows may not be enough to remove it.